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Mostrando ítems 61-70 de 178
Artículo
Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase
(Royal Society of Chemistry (Great Britain), 2011)
A molecular-diversity-oriented approach for the preparation of bicyclic sp2-iminosugar glycomimetics related to nojirimycin and galactonojirimycin is reported. The synthetic strategy takes advantage of the ability of ...
Tesis Doctoral
Síntesis química y enzimática de biofenoles lipofilos del olivo con actividad antiinflamatoria. Optimización de la reacción de Krapcho
(2017-09-15)
En la presente Tesis Doctoral se ha realizado la síntesis de una serie de compuestos lipófilos, a partir de biofenoles contenidos tanto en la hoja de olivo como en el aceite de oliva virgen extra (AOVE), bajo la hipótesis ...
Tesis Doctoral
Síntesis y Estudio de Sistemas Orgánicos con uno o más Espines Electrónicos Desapareados, Altamente Estables y Persistentes, Basados en el Radical BDPA
(2015)
Desde que comenzó su desarrollo a principios del siglo XX, la Química Orgánica de Radicales ha dado lugar a numerosos y diversos tipos de radicales estables, con importantes aplicaciones en el campo de la ciencia de ...
Artículo
Total asymmetric synthesis of monosaccharides and analogues
(Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)
Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid development. The most important methods for the asymmetric synthesis of monosaccharides and analogues of ...
Artículo
Isolation and X-ray characterization of palladium-N complexes in the guanylation of aromatic amines. Mechanistic implications
(2013)
In the context of palladium-catalyzed guanylation of anilines herein, we have been able to characterize and isolate bis(anilino) and bis(guanidino)Pd(II) complexes using reaction conditions under which stoichiometric ...
Artículo
Pyridine-Hydrazone Ligands in Asymmetric Palladium-Catalyzed 1,4- and 1,6-Additions of Arylboronic Acids to Cyclic (Di)enones
(Wiley-Blackwell, 2019)
Catalysts generated by combinations of Pd(TFA)2 and enantiomerically pure pyridine-hydrazone ligands have been applied to the 1,4-addition of arylboronic acids to β-substituted cyclic enones, building all-carbon quaternary ...
Artículo
Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake
(Elsevier, 2019)
In Brazil, cutaneous leishmaniasis is caused predominantly by L. (V.) braziliensis. The few therapeutic drugs available exhibit several limitations, mainly related to drug toxicity and reduced efficacy in some regions. ...
Artículo
Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases
(Wiley-Blackwell, 2017)
Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects towards jack bean α-mannosidase and a Golgi α-mannosidase from Drosophila melanogaster, as well ...
Artículo
Cyclodextrin-mediated Crystallization of Acid β-glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues
(Royal Society of Chemistry, 2011)
Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid β-glucosidase (β-glucocerebrosidase, GlcCerase) with amphiphilic bicyclic nojirimycin analogues of the ...
Artículo
Grafted Sepiolites for the Removal of Pharmaceuticals in Water Treatment
(Springer Nature, 2019)
The increased detection of pharmaceuticals in finished drinking water has become a growing cause of concern in recent years. The removal of atenolol, ranitidine, and carbamazepine by sepiolite, following functionalization ...