Buscar
Mostrando ítems 1-10 de 33
Artículo
Stereoselective enzymatic reduction of 1,4-diaryl-1,4-diones to the corresponding diols employing alcohol dehydrogenases
(MDPI, 2018)
Due to the steric hindrance of the starting prochiral ketones, the preparation of chiral 1,4-diaryl-1,4-diols through the asymmetric hydrogen transfer reaction has been mainly restricted to the use of metal-based catalysts, ...
Artículo
N-Heterotricyclic Cationic Carbene Ligands. Synthesis, Reactivity and Coordination Chemistry
(Royal Society of Chemistry, 2018)
The direct dialkylation of triazolo[4,3-b]isoquinolin-3-ylidene structures readily affords dicationic N-heterotricyclic azolium salts. These are suitable starting materials for the synthesis of transition metal complexes ...
Artículo
Synthesis of β-galactosylamides as Ligands of the Peanut Lectin. Insights into the Recognition Process
(Elsevier, 2017)
The synthesis of mono and divalent β-galactosylamides linked to a hydroxylated chain having a C2 symmetry axis derived from L-tartaric anhydride is reported. Reference compounds devoid of hydroxyl groups in the linker were ...
Artículo
Asymmetric Organocatalytic Synthesis of Fluorinated β-Hydroxy Diazenes
(Wiley-Blackwell, 2019)
The nucleophilic addition of formaldehyde tert-butyl hydrazone to fluoromethyl ketones provides a valuable tool for the synthesis of highly functionalized β-hydroxy β-tri- and difluoromethyl diazenes. Excellent reactivities ...
Artículo
Selenium and Sulphur Derivatives of Hydroxytyrosol: Inhibition of Lipid Peroxidation in Liver Microsomes of Vitamin E-deficient Rats
(Springer Nature, 2019)
Purpose: The objective of this study was to evaluate the capacity of modified phenols synthesized from hydroxytyrosol, a natural olive oil phenol, specifically those containing a selenium or sulphur group, to inhibit lipid ...
Artículo
Role of surface tryptophan for peroxidase oxidation of nonphenolic lignin
(BMC (part of Springer Nature), 2016)
Background: Despite claims as key enzymes in enzymatic delignification, very scarce information on the reaction rates between the ligninolytic versatile peroxidase (VP) and lignin peroxidase (LiP) and the lignin polymer ...
Artículo
Bifunctional Squaramide Organocatalysts for the Asymmetric Addition of Formaldehyde tert-Butylhydrazone to Simple Aldehydes
(Wiley-Blackwell, 2018)
The nucleophilic addition of formaldehyde tert-butylhydrazone to simple aldehydes (a formal hetero-carbonyl–ene reaction) can be performed with good reactivity and excellent enantioselectivity by virtue of the dual ...
Artículo
Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry
(American Chemical Society, 2018)
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out. The combination of the ...
Artículo
Solvent-free synthesis of quaternary alpha-hydroxy alpha-trifluoromethyl diazenes: the key step of a nucleophilic formylation strategy
(Royal Society of Chemistry, 2016)
An efficient, scalable and operationally simple one-pot, 2-step strategy for the nucleophilic formylation of trifluoromethyl ketones is presented. The key step is an unprecedented diaza-carbonyl-ene reaction of formaldehyde ...
Artículo
Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules
(Royal Society of Chemistry, 2016)
A dual drug-loaded HNT–CD glycocluster delivery system based on halloysite nanotubes and carbohydrate functionalized cyclodextrin was developed by a green protocol using solvent-free microwave irradiation. The nanohybrid ...