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Tesis Doctoral
Impacto de la concentración mínima inhibitoria (cmi) y de los puntos de corte clínicos (clsi y eucast) de las combinaciones betalactámicos / inhibidores de betalactamasas en el pronóstico de bacteriemias por enterobacteriaceae
(2017-09-27)
Los puntos de corte clínicos se utilizan para predecir la eficacia terapéutica de un antibiótico cuando se utiliza a la dosis estándar para el tratamiento de una infección causada por el patógeno analizado. Por lo tanto, ...
Artículo
Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains of Klebsiella pneumoniae Producers of Carbapenemase: Role of New Type II Toxin-Antitoxin System, PemIK
(MDPI, 2020-09-02)
Although the failure of antibiotic treatment is normally attributed to resistance, tolerance and persistence display a significant role in the lack of response to antibiotics. Due to the fact that several nosocomial ...
Artículo
In vitro activity of cefiderocol and comparators against isolates of Gram-negative bacterial pathogens from a range of infection sources: SIDERO‑WT‑2014−2018 studies in Spain
(Science Direct, 2021-07-15)
Objectives: The incidence of antimicrobial resistance in Europe is rising. Cefiderocol is approved in Eu- rope for treatment of aerobic Gram-negative bacterial (GNB) infections in adults with limited treatment options. ...
Artículo
Uptake and intracellular activity of linezolid in human phagocytes and nonphagocytic cells
(American Society for Microbiology, 2002-12-01)
The intracellular penetration and activity of linezolid in human polymorphonuclear leukocytes and tissue-cultured cells (McCoy) were evaluated. Linezolid reached intracellular concentrations slightly greater than extracellular ...
Artículo
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum β-lactamase production
(American Society for Microbiology, 2002-12-01)
The relationships between porin deficiency, active efflux of fluoroquinolones, and extended-spectrum β-lactamase (ESBL) production were determined for 53 clinical isolates of Klebsiella pneumoniae. Thirty-two ESBL-positive ...
Tesis Doctoral
Artículo
Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains
(Frontiers Media, 2021)
Carbapenemase-producing Klebsiella pneumoniae infections are an increasing global threat with scarce and uncertain treatment options. In this context, combination therapies are often used for these infections. The bactericidal ...
Artículo
Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences
(Elsevier, 2021)
Objectives The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter species were those of Enterobacter cloacae complex and Enterobacter aerogenes. In 2019, E. ...
Artículo
Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: Mura confers clinical resistance at low fitness cost
(American Society for Microbiology, 2012-05-01)
To determine whether the overexpression of chromosomal genes can confer fosfomycin resistance, genomewide screening of a complete set of 5,272 plasmid-expressed open reading frames of Escherichia coli (ASKA collection) was ...
Artículo
Prospective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenem
(American Society for Microbiology, 2015-06-01)
The aim of this study was to determine the impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2013 by describing the prevalence, dissemination, and geographic distribution of CPE clones, and their ...