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Artículo
Nab2 functions in the metabolism of RNA driven by polymerases II and III
(American Society for Cell Biology, 2011)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One important player in this interface is the poly(A) + -RNA– binding protein Nab2, which ...
Artículo
The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two β-propellers during the assembly of large ribosomal subunits in eukaryotes
(Oxford University Press, 2015)
Ribosome biogenesis is one of the most essential pathways in eukaryotes although it is still not fully characterized. Given the importance of this process in proliferating cells, it is obvious that understanding the ...
Artículo
The dedicated chaperone acl4 escorts ribosomal protein rpl4 to its nuclear pre-60s assembly site
(Public Library of Science, 2015)
Ribosomes are the highly complex macromolecular assemblies dedicated to the synthesis of all cellular proteins from mRNA templates. The main principles underlying the making of ribosomes are conserved across eukaryotic ...
Artículo
Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae
(Oxford University Press, 1999)
Several mutants (spb1-spb7) have been previously identified as cold-sensitive extragenic suppressors of loss-of-function mutations in the poly(A)+-binding protein 1 of Saccharomyces cerevisiae. Cloning, sequence and ...
Artículo
Saccharomyces cerevisiae ribosomal protein L26 is not essential for ribosome assembly and function
(American Society for Microbiology, 2012)
Ribosomal proteins play important roles in ribosome biogenesis and function. Here, we study the evolutionarily conserved L26 inSaccharomyces cerevisiae, which assembles into pre-60S ribosomal particles in the nucle(ol)us. ...
Artículo
Characterization of saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis
(American Society for Microbiology, 2007)
We report the characterization of the yeast Npa2p (Urb2p) protein, which is essential for 60S ribosomal subunit biogenesis. We identified this protein in a synthetic lethal screening with thersa3null allele. Rsa3p is a ...
Artículo
The essential WD-repeat protein Rsa4p is required for rRNA processing and intra-nuclear transport of 60S ribosomal subunits
(Oxford University Press, 2005)
We report the characterization of a novel factor, Rsa4p (Ycr072cp), which is essential for the synthesis of 60S ribosomal subunits. Rsa4p is a conserved WD-repeat protein that seems to localize in the nucleolus.In ...
Artículo
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation
(Oxford University Press, 2017)
Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA polymerases. Transcription elongation involves dynamic interactions between RNA polymerases and ...
Artículo
Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae
(American Society for Microbiology, 1999)