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Artículo
Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe
(Oxford University Press, 2005)
As predicted by the amino acid sequence, the purified protein coded by Schizosaccharomyces pombe SPAC2F7.06c is a DNA polymerase (SpPol4) whose biochemical properties resemble those of other X family (PolX) members. ...
Artículo
Are there mutator polymerases?
(Hindawi Publishing Corporation, 2003)
DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis ...
Artículo
DNA polymerase λ, a novel DNA repair enzyme in human cells
(American Society for Biochemistry and Molecular Biology Inc., 2002)
DNA polymerase lambda (pol λ) is a novel family X DNA polymerase that has been suggested to play a role in meiotic recombination and DNA repair. The recent demonstration of an intrinsic 5′-deoxyribose-5-phosphate lyase ...
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Artículo
Polμ tumor variants decrease the efficiency and accuracy of NHEJ
(Oxford University Press, 2017)
The non homologous end-joining (NHEJ) pathway of double-strand break (DSB) repair often requires DNA synthesis to fill the gaps generated upon alignment of the broken ends, a complex task performed in human cells by two ...
Artículo
Regulation of human Polλ by ATM-mediated phosphorylation during Non-Homologous End Joining
(Elsevier, 2018)
DNA double strand breaks (DSBs) trigger a variety of cellular signaling processes, collectively termed the DNA-damage response (DDR), that are primarily regulated by protein kinase ataxia-telangiectasia mutated (ATM). Among ...
Artículo
An End to a Means: How DNA-End Structure Shapes the Double-Strand Break Repair Process
(Frontiers Media, 2020)
Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5'-phosphate, 3'-hydroxyl moieties at the ends, which are, regardless of the pathway used, ultimately required for their repair. Cells are therefore ...
Artículo
AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants
(Public Library of Science, 2011)
Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by Activation Induced Cytidine Deaminase (AID), triggering class switch recombination (CSR), as well as ...
Artículo
A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis
(Oxford University Press, 2006)
Human DNA polymerase mu (Polm) is a family X member that has terminal transferase activity but, in spite of a non-orthodox selection of the template information, displays its maximal catalytic efficiency in DNA-templated ...