Medicina Preventiva y Salud Pública
https://hdl.handle.net/11441/11049
2024-03-28T09:34:18ZExperiencias de la alianza Ulysseus en mentorización como método de innovación universitaria
https://hdl.handle.net/11441/156484
Experiencias de la alianza Ulysseus en mentorización como método de innovación universitaria
2004-01-01T00:00:00ZTratamiento integral del agua para evitar infecciones parasitarias en comunidades indígenas de Ecuador
https://hdl.handle.net/11441/156230
Tratamiento integral del agua para evitar infecciones parasitarias en comunidades indígenas de Ecuador
Mendoza Muñoz, Yanet
Garantizar el acceso a los servicios de abastecimiento de agua, saneamiento
e higiene es contribuir a mejorar la salud y calidad de vida de las
personas, se estima que alrededor del 10% de la carga de enfermedades
podrían evitarse con acciones de mejora relacionadas con agua potable,
saneamiento e higiene.
2023-01-01T00:00:00ZEnseñanza e innovación educativa en el ámbito universitario
https://hdl.handle.net/11441/156208
Enseñanza e innovación educativa en el ámbito universitario
Llorente Cejudo, Maria del Carmen; Barragán Sánchez, Raquel; Pérez Rodríguez, Noelia; Martín Párraga, Lorena
2024-01-01T00:00:00ZDietary squalene supplementation improvesDSS-induced acute colitis by downregulating p38 MAPKand NFkB signaling pathways
https://hdl.handle.net/11441/156024
Dietary squalene supplementation improvesDSS-induced acute colitis by downregulating p38 MAPKand NFkB signaling pathways
Scope:Squalene is a polyunsaturated triterpene, which has exhibited anticancer and antioxidantactivities among others. We investigated dietary squalene supplementation effect on an acutecolitis model induced by dextran sulfate sodium (DSS) in C57BL/6 mice.Methods and results:Mice were fed from weaning with squalene at 0.02% and 0.1%. After4 weeks, mice were exposed to 3% DSS for 5 days developing acute colitis. After DSS removal(5 days), colons were histological and biochemically processed. Our results showed that dietarysqualene treatment exerts anti-inflammatory action in DSS-induced acute colitis. Western blotrevealed that squalene downregulated COX-2 (where COX is cyclooxygenase) and induciblenitric oxide synthase system by inhibition of mitogen-activated protein kinase p38 and thenuclear factor-kappa B signaling pathways, preventing an increase in the cytokines levels.Under our experimental conditions, STAT3 and FOXP3 (where FOXP3 is forkhead box P3)were not modified and the transcriptional regulation of antioxidant and/or detoxifying enzymes,Nrf2 (where Nrf2 is nuclear factor (erythroid-derived 2)-like 2), was reduced in DSS-inducedcolitis. However, any change could be observed after squalene supplementation.Conclusion:Squalene was able to improve the oxidative events and returned proinflammatoryproteins expression to basal levels probably through p38 mitogen-activated protein kinase andnuclear factor-kappa B signaling pathways. However, supplementary studies are needed inorder to provide a basis for developing a new dietary supplementation strategy.
2015-01-01T00:00:00Z