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Listar por autor "Aguilera López, Andrés"
Mostrando ítems 21-40 de 147
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Artículo
CDK targets Sae2 to control DNA-end resection and homologous recombination
Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Sartori, Alessandro A.; Aguilera López, Andrés; Jackson, Stephen P. (Nature Publishing Group, 2008)DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous ...
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Artículo
Chromosomal translocations caused by either Pol32-dependent or Pol32-independent triparental break-induced replication
Ruiz Pérez, José Francisco; Gómez González, Belén; Aguilera López, Andrés (American Society for Microbiology, 2009)Double-strand breaks (DSBs) are harmful DNA lesions that can generate chromosomal rearrangements or chromosome losses if ...
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Artículo
Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae
Gaillard, Hélène; Aguilera López, Andrés (Public Library of Science, 2014)During transcription, the nascent pre-mRNA undergoes a series of processing steps before being exported to the cytoplasm. ...
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Artículo
Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
Muñoz Galván, Sandra; López Saavedra, Ana; Jackson, Stephen P.; Huertas Sánchez, Pablo; Cortés Ledesma, Felipe; Aguilera López, Andrés (Oxford University Press, 2013)While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of ...
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Artículo
Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases
Pardo, Benjamín; Aguilera López, Andrés (2012) -
Tesis Doctoral
Conexión entre recombinación y biogénesis del RNA: Thp1 y otras proteínas funcionalmente relacionadas
Gallardo Ortega, Mercedes (2003-01) -
Tesis Doctoral
Control genético de las deleciones entre secuencias repetidas directas en Saccaromyces cerevisiae
Prado Velasco, José Félix (1996)Los genomios de todos los organismos están constituidos por un número variable de secuencias repetidas, que pueden llegar ...
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Artículo
Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1
Moriel Carretero, María; Tous Rivera, Cristina; Aguilera López, Andrés (National Academy of Sciences, 2011)Yeast rad3-102, a mutant of the TFIIH complex involved in nucleotide excision repair (NER) and transcription, can perform ...
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Tesis Doctoral
DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity
Marchena Cruz, Esther (2021-10-28)La integridad del genoma es un requisito indispensable para la correcta transmisión de la información genética de una ...
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Artículo
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
Marchena Cruz, Esther; Camino, Lola P.; Bhandari, Jay; Pinela Da Silva, Sonia Cristina; Marqueta Gracia, José Javier; Amdeen, Shahad A.; Guillén Mendoza, Cristina; García Rubio, María Luisa; Calderón Montaño, José Manuel; Xue, Xiaoyu; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2023)Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...
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Artículo
Defective nucleotide excision repair in yeast hpr1 and tho2 mutants
González Barrera, Sergio; Prado Velasco, José Félix; Verhage, Richard; Brouwer, Jaap; Aguilera López, Andrés (Oxford University Press, 2002)Nucleotide excision repair (NER) and transcription are intimately related. First, TFIIH has a dual role in transcription ...
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Artículo
Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
Salas Armenteros, Irene; Barroso Ceballos, Sonia Inés; García Rondón, Ana; Pérez Calero, Mónica; Andújar, Eloísa; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2019)THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
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Capítulo de Libro
Detection of DNA Double-Strand Breaks byγ-H2AX Immunodetection
Barroso, Sonia I.; Aguilera López, Andrés (Humana, 2020)DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage and a cause of geneticinstability as they can ...
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Capítulo de Libro
Detection of DNA-RNA hybrids in vivo
García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Humana Press Inc., 2018)DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they ...
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Artículo
Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication
Cortés Ledesma, Felipe; Tous Rivera, Cristina; Aguilera López, Andrés (Oxford University Press, 2007)Homologous recombination (HR) is the major mechanism used to repair double-strand breaks (DSBs) that result from replication, ...
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Artículo
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
Luna Varo, Rosa María; Japón Rodríguez, Miguel Ángel; Sáez, Carmen; Domínguez Sánchez, María Salud; Aguilera López, Andrés (2011)One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP ...
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Artículo
Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange
Muñoz Galván, Sandra; Tous, Cristina; Blanco, Miguel G.; Schwartz, Erin K.; Ehmsen, Kirk T.; West, Stephen C.; Heyer, Wolf-Dietrich; Aguilera López, Andrés (2012)Most spontaneous DNA double-strand breaks (DSBs) arise during replication and are repaired by homologous recombination ...
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Artículo
Dna-rna hybrids at dsbs interfere with repair by homologous recombination
Ortega Moreno, Pedro; Mérida Cerro, José Antonio; García Rondón, Ana; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2021)DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome ...
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Artículo
DNA-RNA hybrids: The risks of DNA breakage during transcription
Aguilera López, Andrés; Gómez González, Belén (Springer Nature, 2017)Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain ...
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Tesis Doctoral
Elongación de la transcripción en S. cerevisiae el complejo THO y factores relacionados funcionalmente
García Rondón, Ana (2003)La transcripción es el proceso por el cual se copia la información contenida en el DNA, a una molécula de RNA. Se divide ...