Armario‐Hita, José CarlosPereyra-Rodríguez, José-Juande Ortiz de Frutos, Francisco JavierHerranz, PedroSilvestre‐Salvador, Juan FranciscoRodríguez Serna, MercedesSerra, EstherRuiz‐Villaverde, Ricardo2025-06-052025-06-052025-06-01Armario‐Hita, J.C., Pereyra-Rodríguez, J., de Ortiz de Frutos, F.J., Herranz, P., Silvestre‐Salvador, J.F., Rodríguez Serna, M.,...,Ruiz‐Villaverde, R. (2025). Clinical Characteristics, Diagnostic Approaches, Therapeutic Management, and Associated Comorbidities of Prurigo Nodularis (Chronic Nodular Prurigo): An Observational Study in Clinical Practice in Spain. International Journal of Dermatology. https://doi.org/10.1111/ijd.17878.0011-90591365-4632https://hdl.handle.net/11441/173994Background: Prurigo nodularis/chronic nodular prurigo (PN/CNP) is a subtype of chronic prurigo characterized by pruritic nodules on the limbs and trunk. It predominantly affects older adults and women. The multifactorial etiology of PN/CNP complicates its diagnosis and treatment. This study aims to evaluate the clinical characteristics, diagnostic approaches, and patient burden of PN/CNP in Spain. Methods: This observational, cross-sectional, multicenter study was conducted across 12 Spanish hospitals and involved adult patients with PN/CNP. Data were collected from clinical records, patient interviews, and self-administered questionnaires. The study assessed clinical characteristics, diagnostic methods, treatments, and the burden of the disease. Descriptive statistics were used for analysis. Results: A total of 97 patients with PN/CNP were included, 65% of whom were female. The cohort had a mean age of 53 years. Most patients were White (87.5%) with Fitzpatrick phototype III (60.9%). Common comorbidities included dyslipidemia (36.1%), atopic dermatitis (33%), and anxiety/depression (30.9%). Topical treatments were used by 67% of patients, while systemic treatments were used by 63.9%. The average time to diagnosis was 4.5 years, and most patients reported mild to moderate pruritus and pain. Key therapeutic goals included reducing itch intensity (76.3%) and lesion count (37.1%). Overall, 66% of patients were satisfied with their treatment. Conclusion: This study provides a comprehensive profile of patients with PN/CNP in Spain, highlighting complex clinical characteristics and diverse treatment patterns. The findings emphasize the need for innovative, multidisciplinary approaches to the management of PN/CNP to improve patient care and guide future research.application/pdfengAtopic dermatitisChronic prurigoItchPatient carePrurigoPrurigo nodularisPruritusinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/embargoedAccesshttps://doi.org/10.1111/ijd.17878