2025-01-272025-01-272021-09-01González-Serna Martín, M.A., Corma-Gómez, A., Téllez, F., García-Martín, S., Rivero-Juárez, A., Frías, M.,...,Pineda Vergara, J.A. (2021). Liver stiffness change with HCV cure in HIV-infected patients on non-nucleoside analogues. Journal of Antimicrobial Chemotherapy, 76 (9), 2375-2379. https://doi.org/10.1093/jac/dkab157.0305-74531460-2091https://hdl.handle.net/11441/167641Background: Liver stiffness (LS) at sustained viral response (SVR) is strongly associated with a lower incidence of subsequent hepatic events. HIV NNRTIs may have a beneficial impact on fibrogenesis. Objectives: Our aim was to analyse the influence of NNRTI-based therapy on the change in LS from starting direct-acting antiviral (DAA) therapy to achieving SVR in HIV/HCV-coinfected patients. Methods: Three hundred and thirteen HIV/HCV-coinfected patients who fulfilled the following criteria were included: (i) had achieved SVR with an IFN-free, DAA-including regimen; (ii) LS 9.5 kPa before therapy; (iii) LS measurement available at SVR; (iv) seronegative for HBsAg; and (v) ART containing 2 NRTIs plus either 1 NNRTI or 1 integrase inhibitor (INI) or 1 2 NRTIs plus 1 PI. LS changes were assessed. Results: Seventy-four patients received NNRTI-based combinations [53 (71.6%) rilpivirine and 16 (21.6%) efavirenz] and 239 patients received other regimens. At baseline, the median (IQR) LS was 16.7 kPa (11.8 25.6) in the NNRTI group and 17.3 kPa (11.9 27.4) in the non-NNRTI group (P = 0.278). The median (IQR) percentage of LS decrease from baseline to SVR was 35.2% (18.2% 52.3%) for NNRTI-based therapy and 29.5% (10% 45.9%) for PI- or INI-based therapy (P = 0.018). In multivariate analysis, adjusted for sex, age, HCV genotype, NRTI backbone and propensity score for HIV therapy, NNRTI-based regimen use was associated with a higher LS decrease [b = 11.088 (95% CI = 1.67 20.51); P = 0.021]. Conclusions: Treatment with NNRTI plus 2 NRTI combinations is associated with a higher LS decline than other ART combinations in HIV/HCV-coinfected patients receiving DAA-based therapy.application/pdf13 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.1093/jac/dkab157