2024-12-262024-12-262014-072024-12Durán Lobato, M.M., Álvarez Fuentes, J.,...,Martín Banderas, L. (2024). Dataset from Receptor-targeted nanoparticles modulate cannabinoid anticancer activity through delayed cell internalization.. idUS (Depósito de Investigación de la Universidad de Sevilla). https://doi.org/10.12795/11441/166149.https://hdl.handle.net/11441/166149Development and characterization of cannabinoid-loaded receptor-targeted nanoparticles, dual-functionalized with fluorophore probes. The data collects the analysis of the physicochemical properties of the nanoparticles, their capacity to target and exert cytotoxic activity on tumor cells based on their surface modification with transferrin, and the analysis of their cell internalization and subsequent tracking within the cell, monitoring both the nanoparticle core and the encapsulated cargo. The data were generated within the Proyecto de Excelencia de la Junta de Andalucía No. P09-CTS5029, and the aid of a postdoctoral fellowship Contrato Puente Postdoctoral (USE-12003-C) from the V Plan Propio de Investigación of the Vicerrectorado de Investigación from the Universidad de Sevilla.A single Excel file with each sheet collecting the data corresponding to a figure or table: -Table 1: data corresponding to manuscript Table 1 on the physicochemical characterization of the formulations -Figure 2: data corresponding to manuscript Figure 2 displaying the drug release profile of the formulations -Figure 3: data corresponding to manuscript Figure 3 displaying the cell viability results after incubation with the formulations for 2h, 24h and 48h -Figure 4: data corresponding to manuscript Figure 4 displaying the % of fluorescence recovered from the nanoparticle core (FITC signal) and the encapsulated cargo (NR and Rh signal) for either plain and transferrin-modified nanoparticles, with or without the use of endocytosis specific inhibitors. -Figure 5: data corresponding to manuscript Figure 5 b and c, providing quantitative data of nanoparticle cell internalization and intracellular tracking as a function of the fluorescence intensity obtained from both the nanoparticle core (FITC signal) and the delivered cargo (Nile Red and Rhodamine B signal), and the colocalization of both, for both plain and transferrin-modified nanoparticles.application/vnd.ms-excelengAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/CannabinoidesNanopartículas poliméricasTransferrinaCannabinoidsPolymeric nanoparticlesTransferrinIntracellular trackingCancerinfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/openAccess10.12795/11441/166149