Iglesias Linares, AlejandroYañez-Vico, RosaBallesta Mudarra, SofíaOrtiz-Ariza, EstefaníaMendoza Mendoza, María AsunciónPerea Pérez, Evelio JoséMoreno-Fernández, Ana MaríaSolano Reina, José Enrique2017-06-052017-06-052013-04-30Iglesias Linares, A., Yañez-Vico, R., Ballesta Mudarra, S., Ortiz-Ariza, E., Mendoza Mendoza, M.A., Perea Pérez, E.J.,...,Solano Reina, J.E. (2013). Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth. Histology and Histopathology, 28 (6), 767-773.02133911http://hdl.handle.net/11441/60897External pical root resorption (EARR) is a frequent iatrogenic problem following orthodontic treatment in endodontically-treated teeth, about which the literature reports substantial variability in post-orthodontic treatment EARR responses. The main focus of the present study is to clarify whether variants in the interleukin-1 receptor antagonist gene coding for the IL-1ra protein have a positive/negative influence on EARR of endodontically-treated teeth. Ninety-three orthodontic patients were genetically screened for a single nucleotide polymorphism (SNP: rs419598) in the IL1 cluster. The sample was classified into 2 groups: group 1 (affected-group) showed radiographic EARR of more than 2mm; group 2 (control-group), had no EARR or EARR <= to 2mm following orthodontic treatment on root-filled teeth. Logistic regression analysis was performed to obtain an adjusted estimate between the SNPs studied and EARR. Genotype distributions, allelic frequencies, adjusted odds ratios (OR) and 95% confidence intervals were also calculated. We found that subjects homozygous [1/1(TT)] for the IL1RN gene [OR: 10.85; p=0.001; CI: 95%] were at risk of EARR in root-filled teeth. Genetic variants in the antagonist axis balance of the IL1RN(rs419598) have a direct repercussion on the predisposition to post-orthodontic EARR in root-filled teeth. Variants in allele 1 of the interleukin-1 receptor antagonist gene(rs419598) are associated(p=0.001**) with an increased risk of suffering post-orthodontic EARR in root-filled teeth.application/pdfengAttribution 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/External root resorptionInterleukin 1 receptor antagonistEndodontically treated teethOrthodonticsOrthodontic treatmentinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess