2024-07-092024-07-092022Hernández Rodríguez, J.C., Sendín‐Martín, M., Durán Romero, A.J., Ortiz Álvarez, J., Conejo-Mir Sánchez, J. y Pereyra-Rodríguez, J. (2022). Systemic sclerosis mortality trends in Spain from 1980 to 2019: age‐period‐cohort and Joinpoint analysis. Clinical and Experimental Dermatology (CED), 47 (11), 1943-1950. https://doi.org/10.1111/ced.15342.0307-69381365-2230https://hdl.handle.net/11441/161200Background: Systemic sclerosis (SSc) is an autoimmune chronic rheumatic disease with a high mortality rate, which continues to be a challenge for clinicians today. Aim: To assess changes in mortality trends in the Spanish SSc population between 1980 and 2019, taking into account the independent effects of sex, age, time period and birth cohort. Methods: SSc death records and mid-year population data were collected from the National Statistics Institute. Age-standardized mortality rates were calculated for the overall population and for each sex (male, female) and age group (5-year groups). Significant changes in mortality trends were identified by joinpoint regressions. An age-period-cohort (APC) analysis and potential years of life lost (PYLL) analysis were performed to identify the burden of SSc. Results: Age-standardized mortality rates due to SSc increased from 1.87 (95% CI 1.00-3.02) per 1 000 000 inhabitants between 1980 and 1984, to 2.47 (95% CI 1.74-3.02) per 1 000 000 inhabitants between 2015 and 2019. The relative risk of mortality fell in all groups in cohorts born after 1990. The PYLL rates showed a gradual rise for both sexes. Conclusion: There was an increase in overall SSc mortality in Spain during the 39 years evaluated, although there was a progressive drop for men.application/pdf8 p.engScleroderma systemicSurvivalMortalityinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1111/ced.15342