Díez, CristinaRomero-Raposo, Jorge delMicán, RafaelLópez, Juan C.Blanco, José R.Calzado, SoniaLópez Cortés, Luis FernandoGonzález-Serna Martín, Manuel AlejandroPineda Vergara, Juan AntonioMacías Sánchez, JuanMerchante Gutiérrez, NicolásReal Navarrete, Luis Miguel2022-12-012022-12-012021Díez, C., Romero-Raposo, J.d., Micán, R., López, J.C., Blanco, J.R., Calzado, S.,...,Real Navarrete, L.M. (2021). COVID-19 in hospitalized HIV-positive and HIV-negative patients: a matched study. HIV Medicine, 22 (9), 867-876. https://doi.org/10.1111/hiv.13145.1464-2662https://hdl.handle.net/11441/140030Objectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@ Spain cohort. The median age in both groups was 53 (Q1–Q3, 46–56)years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median(Q1–Q3) CD4 count was 595 (349–798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH(P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization.application/pdf10 p.engAtribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/CoronavirusCOVID-19HIVSARS-CoV- 2info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1111/hiv.13145