Studies on the Synthesis of 2-Alkyl-5-aryl-1,3,4-oxadiazolines from N-Acylhydrazones

Marqués López, EugeniaDíez Martín, ElenaMartín Zamora, EloísaÁlvarez González, EleuterioFernández Fernández, Rosario FátimaLassaletta Simón, José María2018-02-092018-02-092012Marqués López, E., Díez Martín, E., Martín Zamora, E., Álvarez, E., Fernández Fernández, R. y Lassaletta Simón, J.M. (2012). Studies on the Synthesis of 2-Alkyl-5-aryl-1,3,4-oxadiazolines from N-Acylhydrazones. Synlett, 23 (6), 885-888.0936-5214https://hdl.handle.net/11441/70183Reaction of N-acylhydrazones with benzyloxyacetyl chloride in the presence of i-Pr 2EtN affords new 1,3,4-oxadiazolines in excellent yields (72-95%), under mild reaction conditions and in short reaction times. The structures of the products were confirmed by single-crystal X-ray diffractometry. A plausible reaction mechanism is proposedapplication/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/AcylationBenzyloxyacetyl chlorideHeterocyclesN -acylhydrazonesOxadiazolinesStudies on the Synthesis of 2-Alkyl-5-aryl-1,3,4-oxadiazolines from N-Acylhydrazonesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1055/s-0031-1290609