Trompier, FrançoisBaumann, MarionBarrios, LleonardGregoire, EricAbend, MichaelAinsbury, ElizabethDomínguez García, InmaculadaMateos Pérez, Juan CarlosRoy, Laurence2022-02-112022-02-112017Trompier, F., Baumann, M., Barrios, L., Gregoire, E., Abend, M., Ainsbury, E.,...,Roy, L. (2017). Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation. International Journal of Radiation Biology, 93 (1), 118-126.0955-3002 impreso1362-3095 onlinehttps://hdl.handle.net/11441/129876Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiation practices in the European biological dosimetry network. Materials and methods: Delivered doses by irradiation facilities used by RENEB partners were determined with EPR/alanine dosimetry system. Dosimeters were irradiated in the same conditions as blood samples. A short survey was also performed to collect the information needed for the data analysis and evaluate the diversity of practices. Results: For most of partners the deviation of delivered dose from the targeted dose remains below 10%. Deviations larger than 10% were observed for five facilities out of 21. Origins of the largest discrepancies were identified. Correction actions were evaluated as satisfactory. The re-evaluation of some ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC) assays has been performed leading to an improvement of the overall performances. Conclusions: This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation.application/pdf9 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/alanine dosimetrybiological dosimetrycalibrationinter-laboratory comparisonquality assuranceinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1080/09553002.2016.1213455