Gonzalo Calvo, Gonzalo de2018-08-062018-08-062018Gonzalo Calvo, G.d. (2018). Lipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary center. Molecules, 23, 1585-1-1585-10.1420-3049https://hdl.handle.net/11441/77844Optically active 1,2-diols are valuable buildings blocks in organic synthesis. In the present paper, a set of racemic 1,2-diols with an ester functional group are prepared, starting from -ketoesters in a three-step procedure with moderate yields. The racemic 1,2-diols, containing a chiral quaternary center in their structure, are subjected to selective acylation in order to perform their kinetic resolution catalysed by a set of commercially available lipases. Under optimized reaction conditions, good conversions and enantioselectivities are achieved by using the lipase PSL-C from Pseudomonas cepacia in tert-butyl methyl ether. This biocatalyst could be reused up to five times without losing its properties.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/BiocatalysisLipasesKinetic resolution1,2-diolsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.3390/molecules23071585