2025-03-112025-03-112024Rodríguez Franco, C., Roldán Molina, E., Aguirre Medina, A., Fernández Fernández, R.F., Hornillos, V. y Lassaletta, J.M. (2024). Catalytic Atroposelective Synthesis of C−N Axially Chiral Aminophosphines via Dynamic Kinetic Resolution. Angewandte Chemie - International Edition, 63 (37), e202409524. https://doi.org/10.1002/anie.202409524.1433-78511521-3773https://hdl.handle.net/11441/169945A ruthenium-catalyzed reductive amination via asymmetric transfer hydrogenation (ATH) has been used to perform an efficient dynamic kinetic resolution (DKR) of N-aryl 2-formyl pyrroles decorated with a phosphine moiety positioned at the ortho’ position. The strategy relies on the labilization of the stereogenic axis in the substrate facilitated by a transient Lewis acid-base interaction (LABI) between the carbonyl carbon and the phosphorus center. The reaction features broad substrate scope of aliphatic amines and N-aryl pyrrole scaffolds, and proceeds under very mild conditions to afford P,N atropisomers in good to high yields and excellent enantioselectivities (up to 99 % ee) for both diphenyl and dicyclohexylphosphino derivatives.application/pdf6 p.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Asymmetric catalysisAxial chiralityDynamic kinetic resolutionRuthenium catalysisTransfer hydrogenationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.1002/anie.202409524