Pérez-Florido, JavierCasimiro-Soriguer, Carlos S.Ortuño, FranciscoFernández-Rueda, José L.Aguado, AndreaLara, MaríaLepe Jiménez, José Antonio2024-02-082024-02-082023Pérez-Florido, J., Casimiro-Soriguer, C.S., Ortuño, F., Fernández-Rueda, J.L., Aguado, A., Lara, M. y Lepe Jiménez, J.A. (2023). Detection of high level of co-infection and the emergence of novel SARS CoV-2 delta-omicron and omicron-omicron recombinants in the epidemiological surveillance of Andalusia. International Journal Of Molecular Sciences, 24 (3), 2419. https://doi.org/10.3390/ijms24032419.1422-0067https://hdl.handle.net/11441/154944Recombination is an evolutionary strategy to quickly acquire new viral properties inherited from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number of co-infections, which constitute the ideal scenario for the emergence of new recombinants. Whole genome sequence of SARS-CoV-2 has been carried out as part of the genomic surveillance programme. Sample sources included the main hospitals in the Andalusia region. In addition to the increase of co-infections and known recombinants, three novel SARS-CoV-2 delta-omicron and omicron-omicron recombinant variants with two break points have been detected. Our observations document an epidemiological scenario in which co-infection and recombination are detected more frequently. Finally, we describe a family case in which co-infection is followed by the detection of a recombinant made from the two co-infecting variants. This increased number of recombinants raises the risk of emergence of recombinant variants with increased transmissibility and pathogenicityapplication/pdf11 p.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/SARS-CoV-2Co-infectionRecombinationSurveillanceEpidemiologyinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.3390/ijms24032419