Vega Moreno, Francisco ManuelRidley, Anne J.2023-10-232023-10-232016-10-23Vega Moreno, F.M. y Ridley, A.J. (2016). The RhoB small GTPase in physiology and disease. Small GTPases, 9 (5), 384-393. https://doi.org/10.1080/21541248.2016.1253528.2154-1248https://hdl.handle.net/11441/149843RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.application/pdf11 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Cancer progressionDevelopmentMembraneTraffickingRhoBRho GTPasesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1080/21541248.2016.1253528