Martínez Gómez, CristinaOlmo Fernández, AlbertoHuertas Sánchez, GloriaPérez García, PabloMaldonado-Jacobi, AndrésYúfera García, Alberto2018-06-122018-06-122017Martínez Gómez, C., Olmo Fernández, A., Huertas Sánchez, G., Pérez García, P., Maldonado Jacobi, A. y Yúfera García, A. (2017). A CMOS Tracking System Approach for Cell Motility Assays. En BIOSTEC 2017: 10th International Joint Conference on Biomedical Engineering Systems and Technologies (229-236), Porto, Portugal: SciTePress Digital Library.978-989-758-216-5https://hdl.handle.net/11441/75995This work proposes a method for studying and monitoring in real-time a single cell on a 2D electrode matrix, of great interest in cell motility assays and in the characterization of cancer cell metastasis. A CMOS system proposal for cell location based on occupation maps data generated from Electrical Cell-substrate Impedance Spectroscopy (ECIS) has been developed. From this cell model, obtained from experimental assays data, an algorithm based on analysis of the 8 nearest neighbors has been implemented, allowing the evaluation of the cell center of mass. The path followed by a cell, proposing a Brownian route, has been simulated with the proposed algorithm. The presented results show the success of the approach, with accuracy over 95% in the determination of any coordinate (x, y) from the expected center of mass.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/ECISBioimpedanceCell CultureCell LocationCell MotilityBrownian MovementCMOSinfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/openAccesshttps://doi.org/10.5220/0006291502290236