Luna Varo, Rosa MaríaGómez González, BelénAguilera López, Andrés2024-08-212024-08-212024-07Luna Varo, R.M., Gómez González, B. y Aguilera López, A. (2024). RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.. Genes & Development, 38 (11-12), 504-527. https://doi.org/10.1101/gad.351853.124..0890-93691549-5477https://hdl.handle.net/11441/162009Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more than four decades, transcription enhances mutation and recombination frequencies. More recent research provided evidence for a previously unforeseen link between RNA and DNA metabolism, which is often related to the accumulation of DNA–RNA hybrids and R-loops. In addition to physiological roles, R-loops interfere with DNA replication and repair, providing a molecular scenario for the origin of genome instability. Here, we review current knowledge on the multiple RNA factors that prevent or resolve R-loops and consequent transcription–replication conflicts and thus act as modulators of genome dynamics.application/pdf25 p.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/DNA–RNA hybridsR-loopsRNA biogenesisRNA metabolismgenome instabilityhelicasesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1101/gad.351853.124.