2023-11-202023-11-202023-10-20Sánchez González, J.M., Silva Viguera, M.d.C., Sánchez González, M.d.C., Capote Puente, R., Hita Cantalejo, M.C.d., Ballesteros Sánchez, A.,...,Gutiérrez Sánchez, E. (2023). Tear Film Stabilization and Symptom Improvement in Dry Eye Disease: The Role of Hyaluronic Acid and Trehalose Eyedrops versus Carmellose Sodium. Journal of Clinical Medicine, 12 (20), 6647. https://doi.org/10.3390/jcm12206647.2077-0383https://hdl.handle.net/11441/151088This study evaluated the effectiveness of hyaluronic acid and trehalose (HA/trehalose) eyedrops in managing dry eye disease (DED) symptoms by measuring tear stability and administering a DED questionnaire. Sixty patients were treated with either HA/trehalose eyedrops (Tear A) or carmellose sodium eyedrops (Tear B) as controls. The tear breakup time (TBUT) and non-invasive breakup time (NIBUT) were monitored, and patients completed the standard patient evaluation of eye dryness (SPEED) questionnaire. After two months of twice-daily applications, patients treated with the HA/trehalose eyedrops demonstrated significant improvements in the NIBUT (12.98 ± 3.22 s) and TBUT (12.95 ± 2.98 s), indicating increased tear stability. Moreover, they reported lower dry eye sensation (6.70 ± 4.94 SPEED score points), suggesting a reduction in DED symptoms. These findings underscore the efficacy of HA/trehalose eyedrops in improving both the objective and subjective signs of DED, with twice-daily application enhancing ocular surface conditions and reducing patient-reported symptoms. © 2023 by the authors.application/pdf11 p.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Artificial tearsCarmellose sodiumDry eye diseaseHyaluronic acidNon-invasive breakup timeStandard patient evaluation of eye drynessSymptom managementTear breakup timeTear film stabilityTrehaloseinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.3390/jcm12206647