Sarmento-Cabral, AndréFuentes Fayos, Antonio C.Mata-Ordoñez, FernandoLeón González, Antonio JoséMartínez Fuentes, Antonio J.Gahete, Manuel D.Luque, Raúl M.2025-06-172025-06-172025-02-06Sarmento-Cabral, A., Fuentes Fayos, A.C., Mata-Ordoñez, F., León González, A.J., Martínez Fuentes, A.J., Gahete, M.D. y Luque, R.M. (2025). From pituitary cells to prostate gland in health and disease: direct and indirect endocrine connections. Reviews in Endocrine and Metabolic Disorders, 26 (2), 187-203. https://doi.org/10.1007/s11154-025-09948-7.1573-26061389-9155https://hdl.handle.net/11441/174417The prostate gland is an endocrine-sensitive organ responding to multiple stimuli. Its development and function are,regulated by multiple hormones (i.e. steroids such as androgens, estrogens and glucocorticoids) but also by other key,hormonal systems such as those comprised by insulin-like growth factor 1 and insulin, which are sourced by different,tissues [e.g. testicles/adrenal-gland/adipose-tissue/liver/pancreas, etc.). Particularly important for the endocrine control,of prostatic pathophysiology and anatomy are hormones produced and/or secreted by different cell types of the pituitary,gland [growth-hormone, luteinizing-hormone, follicle-stimulating hormone, and prolactin, oxytocin, arginine-vasopressin,and melanocyte-stimulating hormone], which affect prostate gland function either directly or indirectly under physiological,and pathophysiological conditions [e.g. metabolic dysregulation (e.g. obesity), and prostate transformations (e.g. prostate,cancer)]. This review summarizes the impact of all pituitary hormone types on prostate gland under these diverse conditions including in vivo and in vitro studies.application/pdf17 p.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/ProstatePituitaryHormonesEndocrine regulationProstate cáncerObesityinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1007/s11154-025-09948-7