2025-04-092025-04-092025da Silva Santos, A.M., Dias, É.R., Osajima, J.A., Orta Cuevas, M.d.M., da Silva Barud, H. y da Silva Filho, E.C. (2025). Chemically Modified Polysaccharide Cryogels and their Performance in Ibuprofen Release. Journal of Molecular Liquids, 428, 127446. https://doi.org/10.1016/j.molliq.2025.127446.1873-31660167-7322https://hdl.handle.net/11441/171632Alternative disease treatment methods, such as controlled drug release systems, provide the administration of specific medications at controlled rates over the long term, minimizing side effects resulting from toxicity and increasing the effectiveness of therapy. The main objective of the present work was to prepare cryogels based on babassu mesocarp and bacterial cellulose that was chemically modified through a copolymerization reaction with acrylamide for use in the controlled release of the drug Ibuprofen. The cryogels was characterized by different techniques, when presented a band around 1700 cm−1 referring to Cdouble bondO, which can be attributed to N, N’-methylene-bis-acrylamide, being an indication of the formation of the large, in addition, they presented indications of an amorphous polymeric matrix. The X-ray tomography images showed two-dimensional images and three-dimensional reconstructions, which could not be seen in the SEM. The results of cryogels loaded with the drug Ibuprofen showed that the samples showed toxicity only at a concentration of 5 mg mL−1. All other cryogel samples were considered non-cytotoxic. Regarding the release of Ibuprofen, there was aelease of the drug in the first 12 h in PBS, and the release in the gastric fluid was slower, but all cryogels tended to release 100 %; these cryogels were promising in the drug release model.application/pdf33 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/BiomaterialDrugsControlled releaseBabassu mesocarpBacterial celluloseinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/embargoedAccess10.1016/j.molliq.2025.127446