Ampuero Herrojo, JavierSánchez-Torrijos, YolandaAguilera, VirginiaBellido, FranciscoRomero Gómez, Manuel2021-05-052021-05-052018-02-23Ampuero Herrojo, J., Sánchez-Torrijos, Y., Aguilera, V., Bellido, F. y Romero Gómez, M. (2018). New therapeutic perspectives in non-alcoholic steatohepatitis. Revista Española De Enfermedades Digestivas, 41 (2), 128-142.1130-0108https://hdl.handle.net/11441/108571Management of non-alcoholic steatohepatitis is focused on restitution of metabolic derangement, weight loss and drugs able to improve steatosis, ballooning and fibrosis. Life-style interventions based on Mediterranean diet and increasing physical activity are the first line ther apy. In patients with unsuccessful life-style intervention several drugs are under development: agonist PPAR, agonist GLP-1R and agonist FXR together with drugs focussing on inflammation, ballooning, apoptosis and fibrosis. Bariatric surgery or advanced endoscopy are reserved for morbid obese without response to life-style intervention and weighting loss drugs.application/pdf15 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Body mass indexVisceral obesityObeticolic acidPeroxisome proliferator-activated receptorGlucagon-like peptide-1 receptor agonistsÍndice de masa corporalObesidad visceralÁcido obeticólicoPeroxisome proliferator activated receptorAgonistas glucagon-like peptide-1 receptorinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1016/j.gastrohep.2017.07.006