Berrougui, HichamLópez Lázaro, MiguelMartín Cordero, CarmenMamouchi, MohamedEttaib, AbdelkaderHerrera González, María Dolores2017-12-132017-12-132005Berrougui, H., López Lázaro, M., Martín Cordero, C., Mamouchi, M., Ettaib, A. y Herrera González, M.D. (2005). Cytotoxic activity of methanolic extract and two alkaloids extracted from seeds of Peganum harmala L.. Journal of Natural Remedies, 5 (1), 41-45.0972-5547 (impreso)http://hdl.handle.net/11441/67610To study the cytotoxic activity of P. harmala. Materials and method: The alkaloids harmine and harmaline have been isolated from a methanolic extract from the seeds of P. harmala L. and have been characterized by spectroscopic-Mass and NMR methods. The cytotoxicity of the methanolic extract and both alkaloids has been investigated in the three human cancer cell lines UACC-62 (melanoma), TK-10 (renal) and MCF-7 (breast) and then compared to the positive control effect of the etoposide. Results and conclusion: The methanolic extract and both alkaloids have inhibited the growth of these three cancer cell-lines and we have discussed possible mechanisms involved in their cytotoxicity.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Peganum harmalaHarmineHarmalineCytotoxicityTK-10MCF-7UACC-62info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess