Martínez Martínez, LuisConejo Gonzalo, Mª CarmenPascual Hernández, ÁlvaroHernández Allés, SantiagoRamírez de Arellano Ramos, E.Benedí, Vicente J.Perea Pérez, Evelio José2017-08-172017-08-172000-09-06Martínez Martínez, L., Conejo Gonzalo, M.C., Pascual Hernández, Á., Hernández Allés, S., Ramírez de Arellano Ramos, E., Benedí, V.J. y Perea Pérez, E.J. (2000). Activities of imipenem and cephalosporins against clonally related strains of Escherichia coli hyperproducing chromosomal β-lactamase and showing altered porin profiles. Antimicrobial Agents and Chemotherapy, 44 (9), 2534-2536.0066-4804 (impreso)1098-6596 (electrónico)http://hdl.handle.net/11441/63826Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, >256 μg/ml) and ceftazidime (MICs, 32 to 256 μg/ml) and were intermediate or resistant to cefotaxime (MICs, 16 to 128 μg/ml) but susceptible to both cefepime (MICs, 0.5 to 2 μg/ml) and imipenem (MICs, 0.125 to 0.25 μg/ml). Resistance to β-lactams was related to high-level production of AmpC β-lactamase and loss of OmpF porin.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1128/AAC.44.9.2534-2536.2000