Gimeno Ferrero, RaúlRodríguez de Jesús, JavierPernia Leal, Manuel2024-12-162024-12-162024Gimeno Ferrero, R., Rodríguez de Jesús, J. y Pernia Leal, M. (2024). Efficient Strategy to Synthesize Tunable pH-Responsive Hybrid Micelles Based on Iron Oxide and Gold Nanoparticles. Langmuir, 40 (22), 11775-11784. https://doi.org/10.1021/acs.langmuir.4c01318.0743-74631520-5827https://hdl.handle.net/11441/165851The preparation of multifunctional nanomaterials based on inorganic nanoparticles with organic materials has emerged as a promising strategy for the development of new nanomedicines for in vitro and in vivo biomedical applications. Here, we synthesized pH-responsive hybrid inorganic micelles by combining a novel pH-responsive amphiphilic molecule with hydrophobic payloads. This amphiphile was synthesized in a one-pot reaction and self-assembled readily into micelles under acidic pH conditions. In the presence of hydrophobic NP payloads such as AuNPs or IONPs, the amphiphile self-organized around them through hydrophobic interactions, resulting in the formation of colloidally stable hybrid micelles. The size of the hydrophobic NPs determined the pH-response of the inorganic hybrid micelles, which is tuned from pH 7 to 11 for our pH-responsive amphiphilic molecule. This achievement represents a novel approach for the synthesis of tunable pH-responsive hybrid micelles based on inorganic NPs for biomedical imaging, hyperthermia treatment, and also drug delivery nanosystems.application/pdf10 p.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/HidrophobicityMetal nanoparticlesMicellesMixturesPHinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/embargoedAccesshttps://doi.org/10.1021/acs.langmuir.4c01318