2022-11-042022-11-042022García García, A., Rojas, S., Rivas García, L., Navarro Hortal, M.D., Romero Márquez, J.M., Fernández-Bolaños Guzmán, J.M.,...,Rodríguez-Diéguez, A. (2022). A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans. Chemical Communications, 58, 1514-1517. https://doi.org/10.1039/d1cc04404d.1359-73451364-548Xhttps://hdl.handle.net/11441/138977A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer’s disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme–substrate complex. Finally, the palladium compound shows promising protective activity against Ab-induced toxicity in the Caenorhabditis elegans model, which has never been reported.application/pdf5 p.engAtribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.1039/d1cc04404d