Hornillos, ValentínRos, Abel2022-05-272022-05-272016Hornillos, V. y Ros, A. (2016). Synthesis of axially chiral heterobiaryl alkynes via dynamic kinetic asymmetric alkynylation. Chemical Communications, 52, 14121-14124.1359-73451364-548Xhttps://hdl.handle.net/11441/133804The dynamic kinetic Pd0 -catalyzed alkynylation of racemic heterobiaryl sulfonates was used for the asymmetric synthesis of axially chiral heterobiaryl alkynes with a broad scope. The use of Pd(OAc)2/ (S)-QUINAP as the precatalyst provides products in excellent yields and enantioselectivities under mild conditions (DMSO, 40 8C). Semireduction, 1,3-dipolar cycladdition or N-oxidation served to illustrate the synthetic potential of the methodology.application/pdf4 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1039/C6CC08997F