2025-06-132025-06-132025-09Başak, O., Kurtuldu, F., Ilavský, J., Vitázková, M., Beltrán, A.M., Muñoz Fraile, F.,...,Chromčíková, M. (2025). Influence of calcium nitrate timing on the structural and textural characteristics of mesoporous SiO₂-CaO nanoparticles. Open Ceramics, 23, 100807. https://doi.org/10.1016/j.oceram.2025.100807.2666-5395https://hdl.handle.net/11441/174301Mesoporous bioactive glass nanoparticles (MBGNPs) are promising materials for drug delivery due to their high pore volume and specific surface area. This study investigates how the timing of calcium nitrate addition affects the structural and textural characteristics of MBGNPs synthesized via a microemulsion-assisted sol-gel method. Delayed calcium nitrate addition reduced CaO incorporation from 14.2 to 9.5 mol% and increased particle size from 178 ± 51 nm to 256 ± 30 nm. The specific surface area values increased with the delayed addition of calcium nitrate, as observed through BET and USAXS/SAXS measurements. The proportion of Qₛᵢⁿ units slightly changed, but no cytotoxicity was observed in osteoblast-like cells. These findings provide valuable insights into optimizing MBGNP synthesis for biomedical applications.application/pdf11 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Mesoporous bioactive nanoparticlesMicroemulsion assisted sol-gel synthesisCalcium nitrate tetrahydrateinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1016/j.oceram.2025.100807