Rosales Martínez, AntonioEnríquez Giraudo, LourdesJaraíz Maldonado, MartínPozo-Morales, LauraRodríguez-García, IgnacioDíaz Ojeda, Emilio2020-09-092020-09-092020-08Rosales Martínez, A., Enríquez Giraudo, L., Jaraíz Maldonado, M., Pozo-Morales, L., Rodríguez-García, I. y Díaz Ojeda, E. (2020). A Concise Route for the Synthesis of Tetracyclic Meroterpenoids: (±)-Aureol Preparation and Mechanistic Interpretation. Marine Drugs, 18 (9), 441-.1660-3397https://hdl.handle.net/11441/100873A new concise general methodology for the synthesis of different tetracyclic meroterpenoids is reported: (±)-aureol (1), the key intermediate of this general route. The synthesis of (±)-aureol (1) was achieved in seven steps (28% overall yield) from (±)-albicanol. The key steps of this route include a C–C bond-forming reaction between (±)-albicanal and a lithiated arene unit and a rearrangement involving 1,2-hydride and 1,2-methyl shifts promoted by BF3•Et2O as activator and water as initiator.application/pdf8 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/AureolTetracyclic meroterpenoidsNatural products synthesisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.3390/md18090441