Orta Cuevas, María del MarMaisanaba Hernández, SaraMedina Carrasco, SantiagoJos Gallego, Ángeles Mencía2025-07-282025-07-282021Orta Cuevas, M.d.M., Maisanaba Hernández, S., Medina Carrasco, S. y Jos Gallego, Á.M. (2021). Potential Application of a Synthetic Organo-funtionalized High Load Expandable Mica as Drug Carrier for Controlled Release.. Current drug delivery, 18 (5), 645-643. https://doi.org/10.2174/1567201817666201022122845.18755704https://hdl.handle.net/11441/175732Background: In this work the cytotoxicity and gastric and gastrointestinal resistance of a high-load synthetic expandable mica, Na-mica-4, is studied for the first time. The hydrophilic character of this clay mineral can be modified by ion exchange reaction between Na+ inorganic cations housed in the interlayer space, and surfactant molecules, resulting in the formation of an organophilic material. This adsorption capability of organic compounds makes them very useful for a wide range of applications, such as their use as drug carriers. Previous studies have shown the high adsorption capacity of organofunctionalized Na-mica-4 of different types of drugs. Objetive: To carry out initial trials aimed at testing the cytotoxicity of a synthetic organofunctional expandable mica and evaluating its resistance to gastric and gastrointestinal digestion. Methods: A highly charged sodium mica (Na-mica-4) was synthesized and organofunctional by cationic exchange with an alkylamine, primary amine of 18 carbon atoms (C18-mica-4). Both were characterized by X-ray diffraction, field transmission electron microscopy, surface-specific analysis, differential scanning calorimetry, and thermal gravimetric analysis. In addition, screening cytotoxicity trials were conducted on the human intestinal cell line Caco-2 with C18-mica-4 (0-125 μg/ml). Results: Only one of the endpoints evaluated (the reduction of tetrazolium MTS salt by dehydrogenase enzymes) showed a significant decrease in cellular viability after 48h at the highest concentration tested. C18-mica-4 shows structural resistance to both, gastric and gastrointestinal, digestion. Conclusion: A successful development of a functionalized mica has been made with a promising potential application as a carrier to the drug.application/pdf11 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/High-charge swelling micaOrgano-functionalizationCytotoxicityDrug carrierCharacterizationSynthetic micainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.2174/1567201817666201022122845