2025-04-222025-04-222024-10-09Martín García, M.T., Maya Díaz, C.M., Galindo del Pozo, A. y Nicasio Jaramillo, M.d.C. (2024). Ni‐Catalyzed (2+2+2) Cycloaddition of Alkynes to Form Arenes and Pyridines at Low Catalyst Loadings. Advanced Synthesis & Catalysis, 367 (4), e202400765. https://doi.org/10.1002/adsc.202400765.1615-41501615-4169https://hdl.handle.net/11441/171910We report the Ni-catalyzed cyclotrimerization of terminal alkynes at very low loadings of catalysts (0.05 mol% for all substrates). The nickel catalyst containing a terphenyl phosphine ligand allows carrying out the reactions at room temperature in only 30 min, providing the arene products as a single regioisomer in most cases. The Ni complex is also competent for the synthesis of polysubstituted pyridines through the cycloadditions of diynes and nitriles at mild temperatures (25 ° or 50 °C) and low Ni loadings (1 mol%). Experimental data and computational studies support the involvement of monoligated PNi species in all fundamental steps of the catalytic cycle.application/pdf10 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/CycloadditionNickelCatalysisPhosphinesAlkynesMechanisminfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.1002/adsc.202400765