Díaz Moreno, IreneVelázquez Cruz, AlejandroCurran French, SeamusDíaz Quintana, Antonio JesúsRosa Acosta, Miguel Ángel de la2019-06-122019-06-122018Díaz Moreno, I., Velázquez Cruz, A., Curran French, S., Díaz Quintana, A.J. y Rosa Acosta, M.Á.d.l. (2018). Nuclear cytochrome c – a mitochondrial visitor regulating damaged chromatin dynamics. FEBS Letters, 592 (2), 172-178.0014-57931873-3468https://hdl.handle.net/11441/87386Over the past decade, evidence has emerged suggesting a broader role for cytochrome c (Cyt c) in programmed cell death. Recently, we demonstrated the ability of Cyt c to inhibit the nucleosome assembly activity of histone chaperones SET/template-activating factor Iβ and NAP1-related protein during DNA damage in humans and plants respectively. Here, we hypothesise a dual concentration-dependent function for nuclear Cyt c in response to DNA damage. We propose that low levels of highly cytotoxic DNA lesions – such as double-strand breaks – induce nuclear translocation of Cyt c, leading to the attenuation of nucleosome assembly and, thereby, increasing the time available for DNA repair. If DNA damage persists or is exacerbated, the nuclear Cyt c concentration would exceed a given threshold, causing the haem protein to block DNA remodelling altogether.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Chromatin remodellingCytochrome cDNA damage responseHistone chaperoneLow-complexity acidic regioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1002/1873-3468.12959