Carbajo Gordillo, Ana IsabelRodríguez Lavado, JulioJiménez Blanco, José LuisBenito Hernández, Juan ManuelDi Giorgio, ChristopheVélaz, ItziarTros de Ilarduya, ConcepciónOrtiz Mellet, CarmenGarcía Fernández, José Manuel2019-09-172019-09-172019-06-19Carbajo-Gordillo, A.I., Rodríguez Lavado, J., Jiménez Blanco, J.L., Benito Hernández, J.M., Di Giorgio, C., Vélaz, I.,...,García Fernández, J.M. (2019). Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties. Chemical Communications, 55 (57), 8227-8230.1359-73451364-548Xhttps://hdl.handle.net/11441/89165An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Transferencia génicaPolietileniminainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1039/c9cc04489b