Rodríguez Gil, AlfonsoCarrillo-Cruz, EstrellaMarrero-Cepeda, CristinaRodríguez, GuillermoPérez Simón, José Antonio2022-11-142022-11-142022Rodríguez Gil, A., Carrillo-Cruz, E., Marrero-Cepeda, C., Rodríguez, G. y Pérez Simón, J.A. (2022). Effect of Vitamin D on Graft-versus-Host Disease. Biomedicines, 10 (5), 987. https://doi.org/10.3390/biomedicines10050987.2227-9059https://hdl.handle.net/11441/139395The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts different functions that influence immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies explored the impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results were confirmed in a prospective cohort trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies was also explored. Considering this dual effect on both the immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be useful in this setting to decrease both graft-versus-host disease and relapse rates.application/pdf26 p.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Vitamin DCalcifediolCalcitriolGraft-versus-host diseaseVitamin D receptor (VDR)info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.3390/biomedicines10050987