García Quintanilla, Meritxell de JesúsCaro Vega, José ManuelPulido, Marina R.Moreno Martínez, P.Pachón Díaz, JerónimoMcConnell, Michael J.2024-06-242024-06-242016-08García Quintanilla, M.d.J., Caro Vega, J.M., Pulido, M.R., Moreno Martínez, P., Pachón Díaz, J. y McConnell, M.J. (2016). Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii. Antimicrob Agents and Chemotherapy, 60 (8), 5076-5079. https://doi.org/10.1128/AAC.00407-16.0066-48041098-6596https://hdl.handle.net/11441/160799LpxC inhibitors have generally shown poor in vitro activity against Acinetobacter baumannii. We show that the LpxC inhibitor PF-5081090 inhibits lipid A biosynthesis, as determined by silver staining and measurements of endotoxin levels, and significantly increases cell permeability. The presence of PF-5081090 at 32 mg/liter increased susceptibility to rifampin, vancomycin, azithromycin, imipenem, and amikacin but had no effect on susceptibility to ciprofloxacin and tigecycline. Potentiating existing antibiotics with LpxC inhibitors may represent an alternative treatment strategy for multidrug-resistant A. baumannii.application/pdf4engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/LpxC inhibitorsAcinetobacter baumanniiAntibioticsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1128/AAC.00407-16