2018-01-292018-01-292014García Domínguez, I., Gotor Martínez, C. y Romero González, L.C. (2014). Beyond toxicity: A regulatory role for mitochondrial cyanide. Plant signaling & behavior, 91559-2316 (impreso)1559-2324 (electrónico)https://hdl.handle.net/11441/69685In non-cyanogenic plants, cyanide is a co-product of ethylene and camalexin biosynthesis. To maintain cyanide at non-toxic levels, Arabidopsis plants express the mitochondrial β-cyanoalanine synthase CYS-C1. CYS-C1 knockout leads to an increased level of cyanide in the roots and leaves and a severe defect in root hair morphogenesis, suggesting that cyanide acts as a signaling factor in root development. During compatible and incompatible plant-bacteria interactions, cyanide accumulation and CYS-C1 gene expression are negatively correlated. Moreover, CYS-C1 mutation increases both plant tolerance to biotrophic pathogens and their susceptibility to necrotrophic fungi, indicating that cyanide could stimulate the salicylic acid-dependent signaling pathway of the plant immune system. We hypothesize that CYS-C1 is essential for maintaining non-toxic concentrations of cyanide in the mitochondria to facilitate cyanide’s role in signaling.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/CyanideMitochondriaß-cyanoalanine synthasePlant immune responseRoot hairCell signalinginfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.4161/psb.27612