Dataset from Enhanced Cellular Uptake and Biodistribution of a Synthetic Cannabinoid Loaded in Surface-Modified PLGA Nanoparticles. Journal of Biomedical Nanotechnology, 10(1), 1-12 (2014) (v.0)

2025-01-092025-01-092012-102024Durán Lobato, M.M., Holgado Villafuerte, M.Á.,...,Martín Banderas, L. (2024). Dataset from Enhanced Cellular Uptake and Biodistribution of a Synthetic Cannabinoid Loaded in Surface-Modified PLGA Nanoparticles. Journal of Biomedical Nanotechnology, 10(1), 1-12 (2014) (v.0). idUS (Depósito de Investigación de la Universidad de Sevilla). https://doi.org/10.12795/11441/166323.https://hdl.handle.net/11441/166323This dataset contains experimental data on the characterization and evaluation of CB13-loaded, PLGA nanoparticles surface-modified with chitosan, lecithin, Eudragit®, and vitamin E. It includes further detailed drug encapsulation efficiency and loading efficiency, in vitro cellular viability and uptake, ex vivo mucoadhesion studies, and in vivo biodistribution assays in mice.A single Excel file with each sheet containing: -Figure 3: Data corresponding to manuscript Figure 3 on entrapment efficiency and drug loading for each of the formulations assayed. -Figure 4: Data corresponding to manuscript Figure 4 on the drug release profile of the different formulations assayed. -Figure 6: Data corresponding to manuscript Figure 6 showing the % of mucoadhesion of the assayed formulations in different regions of the intestinal tract analyzed ex vivo. -Figure 7: Data corresponding to manuscript Figure 7 showing the effect of free CB13, blank PLGA NPs and loaded-PLGA NPs, plain and surface-modified on Caco-2 cells viability after an incubation period of 24h and 4 days. -Figure 8: Data corresponding to manuscript Figure 8 describing the uptake rate of plain and surface-modified NPs in Caco-2 cells -Figure 10: Data corresponding to manuscript Figure 10 showing tissue distribution represented as a measure of the relative percentage of particles detected related to the total particles.application/vnd.ms-excelengAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Cannabinoid agonistPLGANanoparticlesSurface-modifiedOral absorption enhancersDataset from Enhanced Cellular Uptake and Biodistribution of a Synthetic Cannabinoid Loaded in Surface-Modified PLGA Nanoparticles. Journal of Biomedical Nanotechnology, 10(1), 1-12 (2014) (v.0)Data on the characterization, cellular uptake, and biodistribution of CB13-loaded, surface-modified PLGA nanoparticles.info:eu-repo/semantics/datasetinfo:eu-repo/semantics/openAccess10.12795/11441/166323