2025-05-142025-05-142025Montero-Vallejo, R., Maya Miles, D., Ampuero Herrojo, J., Martín, F., Romero Gómez, M. y Gallego Durán, R. (2025). Novel insights into metabolic-associated steatotic liver diseasepreclinical models. Liver International, 44 (3), 644-662. https://doi.org/10.1111/liv.15830.1478-32311478-3223https://hdl.handle.net/11441/172696Metabolic-associated steatotic liver disease (MASLD) encompasses a wide spec-trum of metabolic conditions associated with an excess of fat accumulation in theliver, ranging from simple hepatic steatosis to cirrhosis and hepatocellular carcinoma.Finding appropriate tools to study its development and progression is essential toaddress essential unmet therapeutic and staging needs. This review discusses advan-tages and shortcomings of different dietary, chemical and genetic factors that can beused to mimic this disease and its progression in mice from a hepatic and metabolicpoint of view. Also, this review will highlight some additional factors and considera-tions that could have a strong impact on the outcomes of our model to end up pro-viding recommendations and a checklist to facilitate the selection of the appropriateMASLD preclinical model based on clinical aims.application/pdf19engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Animal modelsLiver fibrosisMASLDSteatohepatitisNovel insights into metabolic-associated steatotic liver diseasepreclinical modelsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1111/liv.15830