2025-01-272025-01-272013-012025-01-27Martín Banderas, L., Muñoz Rubio, I.,...,Fernández Arévalo, M.M. (2025). Dataset of Engineering of Δ9-tetrahydrocannabinol delivery systems based on surface modified-PLGA nanoplatforms. idUS (Depósito de Investigación de la Universidad de Sevilla). https://doi.org/10.12795/11441/167599.https://hdl.handle.net/11441/167599This dataset corresponds to the article "Engineering of Δ9-tetrahydrocannabinol delivery systems based on surface modified-PLGA nanoplatforms." It includes data on the formulation and characterization of Δ9-THC-loaded PLGA nanoparticles (NPs) prepared via nanoprecipitation. Surface modifications include PEG, chitosan and PEG-chitosan coatings. The dataset encompasses particle size, zeta potential, encapsulation efficiency, drug loading, in vitro drug release profiles, cellular uptake (Caco-2 cells), and cytotoxicity assays.A single Excel file with each sheet collecting the data corresponding to a figure or table: -Figure 1: Data corresponding to manuscript Figure 1 on NPs physicochemical characterization. -Figure 3: Data corresponding to manuscript Figure 3 on the release profile of the different formulations at pH 2 and 7.4. -Figure 4: Data corresponding to manuscript Figure 4 on cell uptake of PLGA, PEG-PLGA and PEG-CS-PLGA NPs. -Figure 5: Data corresponding to manuscript Figure 5 on the cytotoxic effect on Caco-2 cells of free 9-THC, plain PLGA THC-loaded NPs, PEG-PLGA THC-loaded NPs, and PEG-CS-PLGA THC-loaded NPs.application/vnd.ms-excelengAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Blood compatibilityCannabinoidsCellular uptakeCytotoxicityPLGA nanoparticlesSurface functionalization9 -TetrahydrocannabinolCompatibilidad sanguíneaCannabinoidesCaptación celularCitotoxicidadNanopartículas de PLGAFuncionalización de superficieΔ9-Tetrahidrocannabinolinfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/openAccess10.12795/11441/167599