2023-07-062023-07-062022Callejón-Leblic, M.A., Martín-Jiménez, D.I., Moreno Luna, R., Palacios García, J.M., Álvarez Cendrero, M., Vizcarra Melgar, J.A.,...,Sánchez Gómez, S. (2022). Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients. Life, 12 (8), 1256. https://doi.org/10.3390/life12081256.2075-1729https://hdl.handle.net/11441/147775Background: Although smell and taste disorders are highly prevalent symptoms of COVID 19 infection, the predictive factors leading to long-lasting chemosensory dysfunction are still poorly understood. Methods: 102 out of 421 (24.2%) mildly symptomatic COVID-19 patients completed a second questionnaire about the evolution of their symptoms one year after the infection using visual analog scales (VAS). A subgroup of 69 patients also underwent psychophysical evaluation of olfactory function through UPSIT. Results: The prevalence of chemosensory dysfunction decreased from 82.4% to 45.1% after 12 months, with 46.1% of patients reporting a complete recovery. Patients older than 40 years (OR = 0.20; 95% CI: [0.07, 0.56]) and with a duration of loss of smell longer than four weeks saw a lower odds ratio for recovery (OR = 0.27; 95% CI: [0.10, 0.76]). In addition, 28 patients (35.9%) reported suffering from parosmia, which was associated with moderate to severe taste dysfunction at the baseline (OR = 7.80; 95% CI: [1.70, 35.8]). Among the 69 subjects who underwent the UPSIT, 57 (82.6%) presented some degree of smell dysfunction, showing a moderate correlation with self-reported VAS (r = −0.36, p = 0.0027). Conclusion: A clinically relevant number of subjects reported persistent chemosensory dysfunction and parosmia one year after COVID-19 infection, with a moderate correlation with psychophysical olfactory tests.application/pdf17 p.engAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Olfactory disordersCOVID-19Prediction modelAnosmiaParosmiaSmell disordersSmell testinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.3390/life12081256