2025-06-092025-06-092025Martínez Loredo, V. y Ordoñez-Carrasco, J.L. (2025). Unpleasant mood reverses satiety's effect on tobacco reinforcement. Drug and alcohol dependence, 273, 112733. https://doi.org/10.1016/j.drugalcdep.2025.112733.0376-8716 (impreso)1879-0046 (electrónico)https://hdl.handle.net/11441/174090Introduction: Despite empirical support of goal-directed behavior models of dependence, the role of mood on substance use is unclear. The Reinforcer Pathology (RP) model may be useful to describe it specific effects in substance-related variables. This study aims to test mood induction’s effect on tobacco demand and integrate results into the RP model. Methods: Sixty-two participants from the general population, aged 18–34, who smoked at least five cigarettes daily and presented no severe mental health conditions completed the study using a two-group design (betweensubject factor: pleasant vs unpleasant mood induction; within factor: pre-, post-induction). They complete measures of mood status, tobacco reinforcing efficacy, delay discounting, depressive, anxiety and stress symptoms, environmental reinforcement, negative/positive urgency and tobacco-related/free reinforcement. Before mood induction, all participants were sated with nicotine after being asked to smoke freely. Results: While pleasant mood reduced intensity, Omax and breakpoint and increased elasticity, unpleasant mood produced the opposite pattern. This effect was dose dependent and effect sizes were large (f = 0.39–0.50). Mood induction did not significantly affect delay discounting significantly. The association between classical RP variables and new candidates (emotional symptoms, pleasant/negative urgency, tobacco-related/free reinforcement) was differently influenced by mood valance (r = |.359–.532|). Conclusion: Results support the goal-directed behavior model of dependence and extend the RP model by integrating the role of mood induction. The effect of mood seems particularly large in intensity, Omax, and elasticity and this effect may depend on emotional regulation skills and contextual variables, such as substance-freeb reinforcement and environmental reward.application/pdf8 p.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Incentive learningMotivating operationMood inductionReinforcer pathologyEmotional regulationTobacco demandDelay discountinginfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.1016/j.drugalcdep.2025.112733