Braidy, NadySmani Hajami, TarikNaziroglu, Mustafa2022-10-172022-10-172021Braidy, N., Smani Hajami, T. y Naziroglu, M. (2021). Editorial: Involvements of TRP channels, oxidative stress and apoptosis in neurodegenerative diseases. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.649230.1664-042Xhttps://hdl.handle.net/11441/137969The oxygen free radicals generated during metabolism can cause cumulative oxidative damage to nucleic acids, lipids, and protein, resulting in structural degeneration, apoptosis, functional decline, and age-related degenerative diseases involving the cardiovascular, endocrine, neurologic, immune, respiratory, gastrointestinal, and reproductive systems. The transient receptor potential (TRP) protein superfamily is composed of several cation-permeable channels that are widely distributed in mammalian cells. TRP channels can be divided into six subfamilies that are dependent on their sequence identity. These channels play a crucial role in the regulation of oxidative stress and should be considered as likely targets for the treatment of age-related neurodegenerative diseases associated with chronic oxidative stress, decreases in metabolic regulation, and cell viability.application/pdf3 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/TRPOxidative stressApoptosisNeurodegenerationAginginfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.3389/fphys.2021.649230