Matador Martínez, EstebanIglesias Sigüenza, Francisco JavierMonge Fernández, DavidMerino, PedroFernández Fernández, Rosario FátimaLassaletta, José M.2022-11-282022-11-282021Matador Martínez, E., Iglesias Sigüenza, F.J., Monge Fernández, D., Merino, P., Fernández Fernández, R.F. y Lassaletta, J.M. (2021). Enantio- and Diastereoselective Nucleophilic Addition of N-tert-Butylhydrazones to Isoquinolinium Ions through Anion-Binding Catalysis. Angewandte Chemie - International Edition, 60 (10), 5096-5101. https://doi.org/10.1002/anie.202012861.1433-78511521-3773https://hdl.handle.net/11441/139856A highly enantio- and diastereoselective thiourea-catalyzed dearomatization of isoquinolines employing N-tert-butylhydrazones as neutral α-azo carbanions and masked acyl anion equivalents has been developed. Experimental and computational data supports the generation of highly ordered complexes wherein the chloride behaves as a template for the catalyst, the hydrazone reagent, and the isoquinolinium cation, providing excellent stereocontrol in the formation of two contiguous stereogenic centers. The ensuing selective and high-yielding transformations provide appealing dihydroisoquinoline derivatives.application/pdf7 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/AcylationAsymmetric catalysisDearomatizationHydrazonesOrganocatalysisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1002/anie.202012861