Miguel Rodríguez, Manuel deFernández-Santos, José MaríaUtrilla Alcolea, José CarmeloCarrillo Vico, AntonioBorrero, J.Conde Amiano, EsperanzaGuerrero Montávez, Juan MiguelMartín Lacave, Inés María2017-05-162017-05-162005-07-01Miguel Rodríguez, M.d., Fernández-Santos, J.M., Utrilla, J.C., Carrillo Vico, A., Borrero, J., Conde Amiano, E.,..., Martín Lacave, I.M.(2005). Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?. Histology and Histopathology, 20 (3), 713-718.02133911http://hdl.handle.net/11441/59852Thyrotropin-releasing hormone (TRH) synthesized in the hypothalamus has the capability of inducing the release of thyroid-stimulating hormone (TSH) from the anterior pituitary, which in turn stimulates the production of thyroid hormones in the thyroid gland. Immunoreactivity for TRH and TRH-like peptides has been found in some tissues outside the nervous system, including thyroid. It has been demonstrated that thyroid C-cells express authentic TRH, affecting thyroid hormone secretion by follicular cells. Therefore, C-cells could have a paracrine role in thyroid homeostasis. If this hypothesis is true, follicular cells should express TRH receptors (TRH-Rs) for the paracrine modulation carried out by C-cells. In order to elucidate whether or not C-cell TRH production could act over follicular cells modulating thyroid function, we studied TRH-Rs expression in PC C13 follicular cells from rat thyroid, by means of immunofluorescence technique and RT-PCR analysis. We also investigated the possibility that C-cells present TRH-Rs for the autocrine control of its own TRH production. Our results showed consistent expression for both receptors, TRH-R1 and TRH-R2, in 6-23 C-cells, and only for TRH-R2 in PC C13 follicular cells. Our data provide new evidence for a novel intrathyroidal regulatory pathway of thyroid hormone secretion via paracrine/autocrine TRH signaling.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Rat thyroidFollicular cellsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess