2025-05-132025-05-132024-01-25Chimenea, A., García Díaz, L. y Antiñolo Gil, G. (2024). Long-term neurodevelopmental outcome after selective fetoscopic laser lherapy for stage I twin-twin transfusion syndrome. Clinical pediatrics, 63 (11), 1528-1536. https://doi.org/10.1177/00099228241227087.0009-92281938-2707https://hdl.handle.net/11441/172662Twin-twin transfusion syndrome (TTTS) is a serious complication in monochorionic (MC) pregnancies. Fetoscopic laser surgery (FLS) is the primary treatment for advanced TTTS, but managing Quintero stage I TTTS is still controversial. We conducted an observational study evaluating the 2-year neurodevelopment of fetuses, which underwent FLS for stage I TTTS, compared with advanced TTTS and uncomplicated monochorionic diamniotic twins (MCDTs). The study included 156 children: 14 in stage I TTTS group, 28 in advanced TTTS group, and 114 in uncomplicated twin group. In stage I TTTS, 92.9% showed normal neurodevelopment, with no severe neurological impairments observed. These results were comparable with uncomplicated twins (92.1% normal neurodevelopment, P = .921, adjusted odds ratio [aOR] = 1.56, 95% confidence interval [CI] = 0.42-5.79; 1.8% severe impairment, P = .617). Advanced TTTS had a non-significant lower rate of normal neurodevelopment (89.3%, P = .710, aOR = 1.31, 95% CI = 0.12-14.87). In conclusion, FLS for stage I TTTS shows favorable long-term neurodevelopmental outcomes, similar to uncomplicated MC pregnancies.application/pdf8 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/FetoscopyMonozygotic twinningNeurodevelopmental outcomeStage I quinteroTwin twin transfusion syndrome.info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess10.1177/00099228241227087