2017-11-222017-11-222011-01-07López Rojas, R., Domínguez-Herrera, J., Mcconnell, M., Dacobo Pérez, F., Smani, Y. y Pachón Díaz, J. (2011). Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii. The Journal of Infectious Diseases, 203 (4), 545-548.0022-1899 (impreso)1537-6613 (electrónico)http://hdl.handle.net/11441/66493Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model of peritoneal sepsis. These results may explain the low incidence and dissemination of colistin resistance in A. baumannii in clinical settings.application/pdfengAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acinetobacter infectionsAcinetobacter baumanniiAnimalsAnti-bacterial agentsBacterial proteinsColistinPeritonitisSepsisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1093/infdis/jiq086