Gutman, Boris A.Van Erp, Theo G.MTordesillas-Gutiérrez, DianaCrespo Facorro, BenedictoSetién Suero, EstherWang, Lei2022-09-152022-09-152022Gutman, B.A., Van Erp, T.G.M., Tordesillas Gutiérrez, D., Crespo Facorro, B., Setién Suero, E. y Wang, L. (2022). A meta-analysis of deep brain structural shape and asymmetryabnormalities in 2,833 individuals with schizophreniacompared with 3,929 healthy volunteers via the ENIGMAConsortium. HUMAN BRAIN MAPPING, 43 (1), 352-372.1065-94711097-0193https://hdl.handle.net/11441/137111Schizophrenia is associated with widespread alterations in subcortical brain structure.While analytic methods have enabled more detailed morphometric characterization,findings are often equivocal. In this meta-analysis, we employed the harmonizedENIGMA shape analysis protocols to collaboratively investigate subcortical brainstructure shape differences between individuals with schizophrenia and healthy con-trol participants. The study analyzed data from 2,833 individuals with schizophreniaand 3,929 healthy control participants contributed by 21 worldwide research groupsparticipating in the ENIGMA Schizophrenia Working Group. Harmonized shape analy-sis protocols were applied to each site's data independently for bilateral hippocam-pus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained fromT1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens,and thalamus in individuals with schizophrenia compared with control participants,more-convex-than-concave shape differences in the putamen and pallidum, and bothconcave and convex shape differences in the caudate. Patterns of exaggerated asym-metry were observed across the hippocampus, amygdala, and thalamus in individualswith schizophrenia compared to control participants, while diminished asymmetryencompassed ventral striatum and ventral and dorsal thalamus. Our analyses also rev-ealed that higher chlorpromazine dose equivalents and increased positive symptomlevels were associated with patterns of contiguous convex shape differences acrossmultiple subcortical structures. Findings from our shape meta-analysis suggest thatcommon neurobiological mechanisms may contribute to gray matter reduction acrossmultiple subcortical regions, thus enhancing our understanding of the nature of net-work disorganization in schizophrenia.application/pdf21 p.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/SchizophreniaStructureSubcortical shapeinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccesshttps://doi.org/10.1002/hbm.25625